KDS2010 : The Breakthrough in Brain Cell Control for Effective Dieting

Introduction : KDS2010

Dieting just got a whole lot more exciting for the health-conscious! Imagine being able to indulge in your favorite foods while effortlessly shedding unwanted pounds. This article unveils the groundbreaking research conducted by the Institute for Basic Science (IBS) that unveils the secrets behind controlling fat metabolism within specialized brain cells called ‘star cells.’ Brace yourself for a dieting revolution that promises exceptional results without any side effects—a glimpse into the future of obesity treatment.

Table of Contents

Deciphering the Enigma: The Importance of Fat Metabolism

A Ray of Hope for Over a Billion Obesity Patients Worldwide

News of a potential game-changer has rippled through the global community of over one billion obesity patients. Led by Dr. No Do-young, Director of the Institute for Basic Science (IBS), and Dr. Lee Chang-jun, Head of the Cognitive and Social Neuroscience Research Group, a breakthrough has been made in understanding how fat metabolism is regulated within star-shaped non-neuronal cells known as ‘astrocytes.’ Furthermore, a novel drug, ‘KDS2010,’ developed by the research team, has demonstrated remarkable weight loss results in animal experiments, all without the need for dietary restrictions.

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The Brain’s Role in Weight Regulation

Unraveling the Brain’s Control over Fat Metabolism

The balance of hunger pangs and internal energy levels is overseen by the brain’s hypothalamus. While it’s been known that neurons in the hypothalamus play a role in fat tissue function, the precise mechanisms of fat metabolism regulation remained elusive.

The research team identified clusters of nerve cells expressing the inhibitory neurotransmitter ‘GABA (Gamma-Aminobutyric Acid)’ receptors specifically in the hypothalamus. In obese mouse models, they observed a significant decrease in the periodic firing of GABRA5 neurons. When the activity of GABRA5 neurons was chemogenetically inhibited, heat generation in fat tissue (energy expenditure) decreased, resulting in weight gain. Conversely, activating GABRA5 neurons in the hypothalamus led to weight loss. GABRA5 neurons in the hypothalamus are, in essence, the key players in weight control.

Star Cells: The Secret Controllers

Astrocytes Modulating GABRA5 Neuron Activity

The research team discovered that star-shaped astrocytes in the hypothalamus regulate the activity of GABRA5 neurons. Reactive astrocytes, which increase in number and size, express the MAO-B enzyme, leading to sustained GABA production that inhibits surrounding GABRA5 neurons. Inhibiting the expression of MAO-B in reactive astrocytes reduced GABA secretion, activating GABRA5 neurons and promoting heat generation in fat tissue, resulting in weight loss without dietary intervention. The MAO-B enzyme in reactive astrocytes has proven to be an effective target for obesity treatment.

A Promising Future: ‘KDS2010’

Moving Towards Clinical Trials

The research took a significant step forward by transferring the technology to NeurobioGen, who is currently conducting Phase 1 clinical trials with ‘KDS2010.’ Phase 2 trials are scheduled for 2024. These trials have shown substantial weight loss and fat reduction without affecting dietary habits.

Dr. Sa Moon-sun, the first author of the study, explained, “Conventional obesity treatments targeting the hypothalamus focused solely on neural mechanisms related to appetite control. To overcome this limitation, we turned our attention to non-neuronal star cells, and we have identified reactive astrocytes as the root cause of obesity.”

Dr. Lee Chang-jun, who led the research, emphasized the seriousness of obesity as a global health threat, stating, “Obesity is classified by the World Health Organization (WHO) as a ’21st-century pandemic,’ and it poses a significant risk to human health as one of the top 10 global health hazards. We hope that KDS2010, the rising star in next-generation obesity treatments, will bring about effective obesity treatment without suppressing appetite.”

The research findings have been published online on September 1st in ‘Nature Metabolism,’ a prestigious academic journal in the field of metabolism with an impact factor of 20.8.


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